CED / AG Neumann

Scientific interest:

We are interested in intestinal wound- and anastomotic healing in inflammatory bowel disease. Our special interest lies in application of nanoparticle-based local and systemic treatment for induction of wound healing during intestinal inflammation.

Current projects:

• Investigation of the use of Ac2-26 loaded nanoparticles for induction of anastomotic healing during inflammatory conditions in the gut
• Assesment of Annexin A1 treatment for prevention of intestional fibrosis following ileocecal resection in a murine model of Crohns disease
• Analysis of Annexin A1 expression in surgical specimen of patients with Crohn´s disease

International collaborations:

Prof. Asma Nusrat and Charles Parkos

Department of Pathology
University of Michigan

Ass. Prof. Nazila Kamaly
Institute of Nanomedicine
TU Copenhagen
Denmark

Most relevant publications:

Neumann PA, Twardy V, Becker F, Geyer C, Schwegmann K, Mohr A, Faust A, Lenz P, Rijcken E. Assessment of MMP-2/-9 expression by fluorescence endoscopy for evaluation of anastomotic healing in a murine model of anastomotic leakage. PLoS One. 2018 

Quiros M*, Nishio H*, Neumann PA*, Siuda D, Brazil JC, Azcutia V, Hilgarth R, O'Leary MN, Garcia-Hernandez V, Leoni G, Feng M, Bernal G, Williams H, Dedhia PH, Gerner-Smidt C, Spence J, Parkos CA, Denning TL, Nusrat A. Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling. J Clin Invest. 2017 *equal contribution 

Leoni G*, Neumann PA*, Kamaly N*, Quiros M, Nishio H, Jones HR, Sumagin R, Hilgarth RS, Alam A, Fredman G, Argyris I, Rijcken E, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Farokhzad OC, Neish AS, Nusrat A. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest. 2015. *equal contribution

Neumann PA, Koch S, Hilgarth RS, Perez-Chanona E, Denning P, Jobin C, Nusrat A. Gut commensal bacteria and regional Wnt gene expression in the proximal versus distal colon. Am J Pathol. 2014

Rijcken E, Sachs L, Fuchs T, Spiegel HU, Neumann PA. Growth factors and gastrointestinal anastomotic healing. J Surg Res. 2014 

Leoni G, Alam A, Neumann PA, Lambeth JD, Cheng G, McCoy J, Hilgarth RS, Kundu K, Murthy N, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Neish AS, Nusrat A. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest. 2013